Targeting Mycobacterium tuberculosis and other microbial pathogens using 1 improved synthetic antibacterial peptides
نویسندگان
چکیده
1 Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada 5 2 Centre for Tuberculosis Research, University of British Columbia, Vancouver, Canada 6 3 Institute for Applied Computer Science, Karlsruhe Institute of Technology (KIT), P.O. Box 3640, 76021 7 Karlsruhe, Germany 8 4 Institute of Microstructure Technology and Institute of Functional Interfaces, Karlsruhe Institute of 9 Technology (KIT), P.O. Box 3640, 76021 Karlsruhe, Germany 10 5 Present Address: Infection and Immunity Research Centre, Department of Clinical Sciences, St 11 George's, University of London, Cranmer Terrace, London SW17 0RE, United Kingdom 12 13 14 + Equal contributors 15
منابع مشابه
Targeting Mycobacterium tuberculosis and other microbial pathogens using improved synthetic antibacterial peptides.
The lack of effective therapies for treating tuberculosis (TB) is a global health problem. While Mycobacterium tuberculosis is notoriously resistant to most available antibiotics, we identified synthetic short cationic antimicrobial peptides that were active at low micromolar concentrations (less than 10 μM). These small peptides (averaging 10 amino acids) had remarkably broad spectra of antimi...
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